Treatment of lithiated 4-methyloxazole with trimethylsilyl chloride gives the alfa-isocyano silyl enol ether which when heated in the presence of potassium hydroxide undergoes ring closure to 2-trimethylsilyloxazole whose reactions with C- and S-electrophiles affords 2-substituted oxazoles
Intramolecular insertion of the isonitrile group into an oxygen-silicon bond. Synthesis of 2-trimethylsilyloxazole via the ?-isocyano silyl enol ether
DONDONI, Alessandro;FANTIN, Giancarlo;FOGAGNOLO, Marco;MEDICI, Alessandro;PEDRINI, Paola
1984
Abstract
Treatment of lithiated 4-methyloxazole with trimethylsilyl chloride gives the alfa-isocyano silyl enol ether which when heated in the presence of potassium hydroxide undergoes ring closure to 2-trimethylsilyloxazole whose reactions with C- and S-electrophiles affords 2-substituted oxazolesFile in questo prodotto:
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