Pietrogrande, M.C., Dondi, F., Borea, P.A. and Bighi, C., 1989. Principal component analysis in structure-retention and retention-activity studies of benzodiazepines. Chemometrics and Intelligent Laboratory Systems, 5: 257-262. Chromatographic data for a series of thirteen benzodiazepines on six different reversed- and normal-phase systems were analyzed with the help of principal component analysis. Various structure-related descriptors were studied in order to derive information on hydrophobic, electronic and steric properties of solute molecules. Such a data processing strategy is useful in describing the relationship between benzodiazepine molecular structures and their chromatographic retention or their biological activity. © 1989.

Principal analysis in structure retention and retention activity studies of benzodiazepines

PIETROGRANDE, Maria Chiara;DONDI, Francesco;BOREA, Pier Andrea;BIGHI, Corrado
1989

Abstract

Pietrogrande, M.C., Dondi, F., Borea, P.A. and Bighi, C., 1989. Principal component analysis in structure-retention and retention-activity studies of benzodiazepines. Chemometrics and Intelligent Laboratory Systems, 5: 257-262. Chromatographic data for a series of thirteen benzodiazepines on six different reversed- and normal-phase systems were analyzed with the help of principal component analysis. Various structure-related descriptors were studied in order to derive information on hydrophobic, electronic and steric properties of solute molecules. Such a data processing strategy is useful in describing the relationship between benzodiazepine molecular structures and their chromatographic retention or their biological activity. © 1989.
1989
Pietrogrande, Maria Chiara; Dondi, Francesco; Borea, Pier Andrea; Bighi, Corrado
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460553
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 13
social impact