A new series of 1,​4-​dihydropyridine bearing substituted pyrazole and imidazole at C-​4 position was synthesized and characterized as inotropic, chronotropic and calcium antagonist agents, in order to evaluate the effect on pharmacol. activity of replacement of the 4-​aryl group of nifedipine-​like drugs by pyrazole and imidazole moieties. All compds. were tested on myocardial muscle and vascular smooth muscle of guinea-​pigs. The new compds. showed both significant selective neg. inotropic activity and fairly good neg. chronotropic effects. All compds. elicited weak calcium antagonist activity, except one compd. which is a selective bradycardic agent.

Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridinedicarboxylates. 2

BARALDI, Pier Giovanni;CACCIARI, Barbara;
1993

Abstract

A new series of 1,​4-​dihydropyridine bearing substituted pyrazole and imidazole at C-​4 position was synthesized and characterized as inotropic, chronotropic and calcium antagonist agents, in order to evaluate the effect on pharmacol. activity of replacement of the 4-​aryl group of nifedipine-​like drugs by pyrazole and imidazole moieties. All compds. were tested on myocardial muscle and vascular smooth muscle of guinea-​pigs. The new compds. showed both significant selective neg. inotropic activity and fairly good neg. chronotropic effects. All compds. elicited weak calcium antagonist activity, except one compd. which is a selective bradycardic agent.
1993
Baraldi, Pier Giovanni; Garuti, L.; Leoni, A.; Cacciari, Barbara; Budriesi, R.; Chiarini, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460443
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