A new synthesis of geiparvarin and its dihydroderivative two naturally occurring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described. The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin
BARALDI, Pier Giovanni
Primo
;BARCO, AchilleSecondo
;BENETTI, Simonetta;CASOLARI, Alberto;MANFREDINI, Stefano;POLLINI, Gian PieroPenultimo
;SIMONI, DanieleUltimo
1988
Abstract
A new synthesis of geiparvarin and its dihydroderivative two naturally occurring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described. The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.File in questo prodotto:
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