A formal synthesis of (±)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework required for assembling the pyranone unit. The synthetic sequence constitues a new synthetic route to the natural target since the enone 29 has been previously converted to (±)forskolin.

A formal total synthesis (±)-forskolin through [3+2] nitrile oxide cycloaddition chemistry

BARCO, Achille
Primo
;
BENETTI, Simonetta
Secondo
;
SPALLUTO G.;CASOLARI, Alberto;POLLINI, Gian Piero;ZANIRATO, Vinicio
Penultimo
;
BARALDI, Pier Giovanni
Ultimo
1991

Abstract

A formal synthesis of (±)-forskolin 1 has been accomplished utilizing 1,3-dipolar nitrile oxide cycloaddition chemistry either for an alternative and convenient preparation of the key enedione starting building block 3 as well as for the introduction of the suitably functionalized carbon framework required for assembling the pyranone unit. The synthetic sequence constitues a new synthetic route to the natural target since the enone 29 has been previously converted to (±)forskolin.
1991
Barco, Achille; Benetti, Simonetta; Spalluto, G.; Casolari, Alberto; Pollini, Gian Piero; Zanirato, Vinicio; Baraldi, Pier Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460405
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