The ability of a selective agonist for NK-2 tackhykinin receptors to stimulate micturition in anaesthetised rats and guinea-pigs was investigated. In both species, the intravesical instillation of the peptide at uM concentrations reduced bladder capacity and residual volume, indicating a facilitatory effect on reflex micturition, whereas no plasma extravasation was produced as determined by Evans Blue leakage. In experiments on the isolated rat or guinea-pig bladder strips, the peptide induced powerful contractions. In a in vitro model of the guinea-pig whole bladder the intravesical instillation of the agonist facilitated the occurrence of rhythmic contractile activity. The selective NK-2 receptor agonist is likely able to cross the urothelium and stimulate smooth muscle contraction.

Facilitation of reflex micturition by intravesical administration of [bAla8]-neurokinin A (4-10), a selective NK-2 tachykinin receptor agonist.

ABELLI, Luigi;
1991

Abstract

The ability of a selective agonist for NK-2 tackhykinin receptors to stimulate micturition in anaesthetised rats and guinea-pigs was investigated. In both species, the intravesical instillation of the peptide at uM concentrations reduced bladder capacity and residual volume, indicating a facilitatory effect on reflex micturition, whereas no plasma extravasation was produced as determined by Evans Blue leakage. In experiments on the isolated rat or guinea-pig bladder strips, the peptide induced powerful contractions. In a in vitro model of the guinea-pig whole bladder the intravesical instillation of the agonist facilitated the occurrence of rhythmic contractile activity. The selective NK-2 receptor agonist is likely able to cross the urothelium and stimulate smooth muscle contraction.
1991
Maggi, Ca; Giuliani, S; Santicioli, P; Abelli, Luigi; Giachetti, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460131
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