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EnglishLewy pathology in Parkinson disease (PD) extends well beyond the CNS, also affecting peripheral autonomic neuronal circuits, especially the enteric nervous system (ENS). The ENS is an integrative neuronal network also referred to as "the brain in the gut" because of its similarities to the CNS. We have recently shown that the ENS can be readily analyzed using routine colonic biopsies. This led us to propose that the ENS could represent a unique window to assess the neuropathology in living patients with PD. In this perspective, we discuss current evidence which indicates that the presence of ENS pathology may by exploited to improve our understanding and management of PD and likely other neurodegenerative disorders.
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| Data di pubblicazione: | 2011 | |
| Titolo: | Parkinson disease: the enteric nervous system spills its guts | |
| Autori: | Derkinderen, P; Rouaud, T; Lebouvier, T; Bruley des Varannes, S; Neunlist, M; DE GIORGIO, Roberto | |
| Rivista: | NEUROLOGY | |
| Keywords: | enteric nervous system; gut; Parkinson disease | |
| Abstract: | Lewy pathology in Parkinson disease (PD) extends well beyond the CNS, also affecting peripheral autonomic neuronal circuits, especially the enteric nervous system (ENS). The ENS is an integrative neuronal network also referred to as "the brain in the gut" because of its similarities to the CNS. We have recently shown that the ENS can be readily analyzed using routine colonic biopsies. This led us to propose that the ENS could represent a unique window to assess the neuropathology in living patients with PD. In this perspective, we discuss current evidence which indicates that the presence of ENS pathology may by exploited to improve our understanding and management of PD and likely other neurodegenerative disorders. | |
| Digital Object Identifier (DOI): | 10.1212/WNL.0b013e318236ef60 | |
| Handle: | http://hdl.handle.net/11392/2375059 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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