The olfactory bulb (OB), the first center processing olfactory information, is characterized by a vigorous life-long activity-dependent plasticity responsible for a variety of odor-evoked behavioral responses. It hosts the more numerous group of dopaminergic (DA) neurones in the central nervous system, cells strategically positioned at the entry of the bulbar circuitry, directly in contact with the olfactory nerve terminals, which play a key role in odor processing and in the adaptation of the bulbar network to external conditions. Here, we focus mainly on the electrophysiological properties of DA interneurones, reviewing findings concerning their excitability profiles in adulthood and in different phases of adult neurogenesis. We also discuss dynamic changes of the DA interneurones related to environmental stimuli and their possible functional implications.

Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective

PIGNATELLI, Angela
Primo
;
BELLUZZI, Ottorino
Secondo
2017

Abstract

The olfactory bulb (OB), the first center processing olfactory information, is characterized by a vigorous life-long activity-dependent plasticity responsible for a variety of odor-evoked behavioral responses. It hosts the more numerous group of dopaminergic (DA) neurones in the central nervous system, cells strategically positioned at the entry of the bulbar circuitry, directly in contact with the olfactory nerve terminals, which play a key role in odor processing and in the adaptation of the bulbar network to external conditions. Here, we focus mainly on the electrophysiological properties of DA interneurones, reviewing findings concerning their excitability profiles in adulthood and in different phases of adult neurogenesis. We also discuss dynamic changes of the DA interneurones related to environmental stimuli and their possible functional implications.
2017
Pignatelli, Angela; Belluzzi, Ottorino
File in questo prodotto:
File Dimensione Formato  
fnana-11-00007.pdf

accesso aperto

Descrizione: Full text ed
Tipologia: Full text (versione editoriale)
Licenza: Creative commons
Dimensione 885.34 kB
Formato Adobe PDF
885.34 kB Adobe PDF Visualizza/Apri

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2367036
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 38
social impact