Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andrés et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A2B subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A2A and A2B agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A2B and increased A2A.

Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andres et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A(2B) subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A(2A) and A(2B) agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A(2B) and increased A(2A).

Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment

MERIGHI, Stefania;BOREA, Pier Andrea;VARANI, Katia;GESSI, Stefania
2017

Abstract

Purinergic signaling is involved in psoriasis, a chronic skin disease characterized by increased epidermis cell growth. In particular, Andres et al. focus on the keratinocyte biology modulated by adenosine receptors providing evidence that the A(2B) subtype plays a prominent role in the reduction of keratinocyte proliferation whereas A(2A) and A(2B) agonists have antiinflammatory effects independent of adenosine receptors. The authors report that psoriatic epidermis presents a deregulated adenosine receptor expression profile with reduced A(2B) and increased A(2A).
2017
Merighi, Stefania; Borea, Pier Andrea; Varani, Katia; Gessi, Stefania
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2360034
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