A Methodological Approach in Deep Venous Thrombosis Fatal Cases: Clinical Diagnosis, Therapy, Genetics, and a Histopathological Approach.

After attending this presentation, attendees will see how clinical diagnosis of pulmonary embolism (PE) is notoriously inaccurate, with many cases either wrongly diagnosed (overdiagnosed) or missed (underdiagnosed), and autopsy is still considered as the diagnostic gold standard. The accuracy of antemortem diagnosis of pulmonary embolism is within the range of just 10–30%, so representing one of the most frequent missed diagnoses in sudden, unexpected death. Abnormalities within the gene loci encoding for natural anticoagulants (antithrombin, protein C, and protein S) and for fibrinogen have been shown to be rather uncommon risk factors for VTE. The goal of this study was to verify the systematic search for the most common genetic thrombophilias (Factor V Leiden (G1691A)) and FII ((G20210A) gene variants) and dating the thrombus.