Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1.
A small molecule targeting the multifactorial nature of Alzheimer's disease
CAPSONI, Simona;
2007
Abstract
Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1.File in questo prodotto:
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