OBJECTIVE: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. METHODS: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ([Formula: see text]), nitrates ([Formula: see text]), pH, hydrogen peroxide (H2O2) and ammonium ([Formula: see text]) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. RESULTS: Levels of MDA-EBC, 4-HNE-EBC and [Formula: see text]-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, [Formula: see text]-EBC and pH. 4-HNE-EBC correlated with PTX3. CONCLUSION: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners.
CASIMIRRI, Enrico;STENDARDO, Mariarita;BONCI, Melissa;SCHITO, Michela;VACCARI, Alice;PAPI, Alberto;CONTOLI, Marco;BOSCHETTO, Piera
2015
Abstract
OBJECTIVE: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. METHODS: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ([Formula: see text]), nitrates ([Formula: see text]), pH, hydrogen peroxide (H2O2) and ammonium ([Formula: see text]) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. RESULTS: Levels of MDA-EBC, 4-HNE-EBC and [Formula: see text]-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, [Formula: see text]-EBC and pH. 4-HNE-EBC correlated with PTX3. CONCLUSION: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
