L-dopa remains the mainstay treatment for Parkinson’s disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.

L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum

MARTI, Matteo;MORARI, Michele;
2014

Abstract

L-dopa remains the mainstay treatment for Parkinson’s disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.
2014
G., Porras; P., De Deurwaerdere; Q., Li; Marti, Matteo; R., Morgenstern; R., Sohr; E., Bezard; Morari, Michele; W. G., Meissner
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2271214
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