L-Carnitine, a natural mol. provided of specific transporters through the blood-brain barrier (BBB), was coordinated for the 1st time to Pt(II) giving [Pt(PPh3)2(L-carnitine-O,O')]BF4 (1), cis-[Pt(PPh3)2(L-carnitine-O)2](BF4)2 (2) and cis-[Pt(PPh3)2(L-carnitine-O)Cl]BF4 (3). The x-ray crystal structure of complex 1 is the 1st reported for a Pt carnitine complex. The antiproliferative activity of 1, 2 and 3, in comparison with L-carnitine, cis-[PtCl2 (PPh3)2] and cisplatin, were tested against three human tumoral cell lines.
Synthesis, characterization and antiproliferative activity of three platinum(II) complexes of L-carnitine. The first structural determination of a platinum complex containing carnitine
BERGAMINI, Paola;FERRETTI, Valeria;FORMAGLIO, Paolo;MARCHI, Andrea;MARVELLI, Lorenza;SFORZA, Fabio
2014
Abstract
L-Carnitine, a natural mol. provided of specific transporters through the blood-brain barrier (BBB), was coordinated for the 1st time to Pt(II) giving [Pt(PPh3)2(L-carnitine-O,O')]BF4 (1), cis-[Pt(PPh3)2(L-carnitine-O)2](BF4)2 (2) and cis-[Pt(PPh3)2(L-carnitine-O)Cl]BF4 (3). The x-ray crystal structure of complex 1 is the 1st reported for a Pt carnitine complex. The antiproliferative activity of 1, 2 and 3, in comparison with L-carnitine, cis-[PtCl2 (PPh3)2] and cisplatin, were tested against three human tumoral cell lines.File in questo prodotto:
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