RB orchestrates fat cell and cell fate

The novel functions assigned to RB family members in controlling several aspects of stem cell biology open an important scenario not only in terms of basic research, but also for regenerative medicine applications and therapeutics interventions. it is, in fact, very important to attribute new roles to known proteins, to identify new molecular targets to facilitate the develop- ment of cellular therapeutics to replace dam- aged, diseased, or aged tissues. it is possible that retinoblastoma proteins play a complex role in adipogenesis as well as in other differen- tiation processes supported by microenvi- ronmental niche of the adult stem cells.