The project is based on the cooperative efforts of four Units which will pursue the objectives using integrated approaches at cellular and molecular biology, biochemistry, neurochemistry, animal models of neurodegenerative disorders and synaptic physiology levels. Thus, a multidisciplinary approach will be followed, based on the expertise that the Units have developed in the field on PD and dyskinesia. This will lead to two major Objectives: 1) Characterization of the glutamatergic synapse in the striatum of control and early parkinsonian rats: identification of a new therapeutic strategy able to improve motor behavior rebalancing NMDA receptor subunit composition This result will lead to the identification of a new therapeutic strategy able to improve motor behavior rebalancing NMDA receptor subunit composition. 2) Characterization of the molecular mechanisms underlying L-DOPA-induced dyskinesia in the corticostriatal terminals in early and advanced parkinsonism: identification of a new therapeutic strategy This result will lead to the identification of a new therapeutic strategy able to decrease the development of dyskinetic movements rebalancing NMDA receptor subunit composition in dyskinetic animals.
NMDA receptor modulation in early Parkinsonism and L-DOPA-induced discinesia: a new therapeutic strategy
MARTI, Matteo
2010
Abstract
The project is based on the cooperative efforts of four Units which will pursue the objectives using integrated approaches at cellular and molecular biology, biochemistry, neurochemistry, animal models of neurodegenerative disorders and synaptic physiology levels. Thus, a multidisciplinary approach will be followed, based on the expertise that the Units have developed in the field on PD and dyskinesia. This will lead to two major Objectives: 1) Characterization of the glutamatergic synapse in the striatum of control and early parkinsonian rats: identification of a new therapeutic strategy able to improve motor behavior rebalancing NMDA receptor subunit composition This result will lead to the identification of a new therapeutic strategy able to improve motor behavior rebalancing NMDA receptor subunit composition. 2) Characterization of the molecular mechanisms underlying L-DOPA-induced dyskinesia in the corticostriatal terminals in early and advanced parkinsonism: identification of a new therapeutic strategy This result will lead to the identification of a new therapeutic strategy able to decrease the development of dyskinetic movements rebalancing NMDA receptor subunit composition in dyskinetic animals.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
