MTX can induce the in vitro production of circulating HLA-G molecules with interindividual differences. The highest production of sHLA-G molecules is associated with the presence of the deletion (-14/-14 bp) genotype. In rheumatoid arthritis it seems to be important to consider the concurrence of different genetic polymorphisms to help to predict the clinical respose toMTX treatment.
In rheumatoid arthritis a polymorphism in the HLA-G gene concurs in the clinical response to MTX treatment.
BARICORDI, Olavio;GOVONI, Marcello;RIZZO, Roberta;TROTTA, Francesco
2007
Abstract
MTX can induce the in vitro production of circulating HLA-G molecules with interindividual differences. The highest production of sHLA-G molecules is associated with the presence of the deletion (-14/-14 bp) genotype. In rheumatoid arthritis it seems to be important to consider the concurrence of different genetic polymorphisms to help to predict the clinical respose toMTX treatment.File in questo prodotto:
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