Recent publication by Deshmukh et al provided important data on the prevalence of Takotsubo cardiomyopathy (TTC) in the Unites States. Such data are particularly relevant since they refer to more than 6,800 cases, whereas a recent systematic review of 19 available studies, investigating the occurrence of TTC, accounted for 391 cases only. Among the others, Deshmukh et al found a highest peak in July, and a lowest in January. Such observation is in agreement with previous data, but not with other reports. It has to been stressed, however, that all these studies focused on peaks and troughs of TTC, but did not search for possible repeatability. As for this aspect, data from the Takotsubo Italian Network, elaborated through a validated chronobiological software, first reported a seasonal cyclicity in TTC occurrence, characterized by a peak in July and a trough in January, independent of age. Again, the same Italian authors reported also a weekly pattern, characterized by a peak of onset on Monday, not replicated by others. On one hand, Summer seems to be confirmed as a risk period for TTC. On the other, given the great relevance of the population studied by Deshmukh et al, it should be very interesting to test the hypothesis of a cyclical chronobiological pattern by day-of-week. The demonstration of temporal windows at enhanced risk of occurrence may have implications for possible prevention, to try to ensure maximal benefit during vulnerable periods.

Takotsubo cardiomyopathy and summer: A dangerous liaison?

MANFREDINI, Roberto;FABBIAN, Fabio;MANFREDINI, Fabio;
2013

Abstract

Recent publication by Deshmukh et al provided important data on the prevalence of Takotsubo cardiomyopathy (TTC) in the Unites States. Such data are particularly relevant since they refer to more than 6,800 cases, whereas a recent systematic review of 19 available studies, investigating the occurrence of TTC, accounted for 391 cases only. Among the others, Deshmukh et al found a highest peak in July, and a lowest in January. Such observation is in agreement with previous data, but not with other reports. It has to been stressed, however, that all these studies focused on peaks and troughs of TTC, but did not search for possible repeatability. As for this aspect, data from the Takotsubo Italian Network, elaborated through a validated chronobiological software, first reported a seasonal cyclicity in TTC occurrence, characterized by a peak in July and a trough in January, independent of age. Again, the same Italian authors reported also a weekly pattern, characterized by a peak of onset on Monday, not replicated by others. On one hand, Summer seems to be confirmed as a risk period for TTC. On the other, given the great relevance of the population studied by Deshmukh et al, it should be very interesting to test the hypothesis of a cyclical chronobiological pattern by day-of-week. The demonstration of temporal windows at enhanced risk of occurrence may have implications for possible prevention, to try to ensure maximal benefit during vulnerable periods.
2013
Manfredini, Roberto; Fabbian, Fabio; Manfredini, Fabio; Eagle, Ka; Bossone, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1748902
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