The administration of bis-cyclohexylammonium sulphate (BCHS), an inhibitor of spermidine synthase, to cultured chick embryo fibroblasts provoked alterations in cell morphology, a marked disorganization of microfilaments and changes in microtubule network structure. In addition, the rate of microtubule reappearance, after disrupting them with colchicine, was impaired by BCHS. These responses to BCHS were prevented by spermidine addition, which thus suggests an involvement of spermidine in microtubule and microfilament organization.

Effects of spermidine synthase inhibition on cytoskeletal organization in cultured chick embryo fibroblasts.

CARUSO, Angelo;PELLATI, Agnese;
1994

Abstract

The administration of bis-cyclohexylammonium sulphate (BCHS), an inhibitor of spermidine synthase, to cultured chick embryo fibroblasts provoked alterations in cell morphology, a marked disorganization of microfilaments and changes in microtubule network structure. In addition, the rate of microtubule reappearance, after disrupting them with colchicine, was impaired by BCHS. These responses to BCHS were prevented by spermidine addition, which thus suggests an involvement of spermidine in microtubule and microfilament organization.
1994
Caruso, Angelo; Pellati, Agnese; G., Bosi; N., Arena; G., Stabellini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1736517
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