Background. We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE). Methods. In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we: 1) calcu- lated cumulative incidences of PD during the period 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey; 2) identified MWCE from 1869 onwards in Iceland; 3) estimated cohort ages at onset of incidence period and at first MWCE; and 4) combined the above-mentioned information using log-linear models. In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period. Results. The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed: 1) a similar, age-related, inverted V profile; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nine MWCE identified during the period 1869-1927. When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% per year (95% Cl : -0.1-18.3%). Conclusions. These results are consistent with reported effects of age at exposure in animal models of toxic parkin- sonism, age-related changes in the dopamine receptor-GPT-binding protein-adenylatecyclase system observed in rats treated with pertussis toxin, and some PD epidemiological features. They suggest that pertussis neurotoxicity could be causally related to PD worldwide.
Whooping cough and Parkinson's disease.
CASETTA, Ilaria
1996
Abstract
Background. We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE). Methods. In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we: 1) calcu- lated cumulative incidences of PD during the period 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey; 2) identified MWCE from 1869 onwards in Iceland; 3) estimated cohort ages at onset of incidence period and at first MWCE; and 4) combined the above-mentioned information using log-linear models. In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period. Results. The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed: 1) a similar, age-related, inverted V profile; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nine MWCE identified during the period 1869-1927. When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% per year (95% Cl : -0.1-18.3%). Conclusions. These results are consistent with reported effects of age at exposure in animal models of toxic parkin- sonism, age-related changes in the dopamine receptor-GPT-binding protein-adenylatecyclase system observed in rats treated with pertussis toxin, and some PD epidemiological features. They suggest that pertussis neurotoxicity could be causally related to PD worldwide.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
