Linearity conditions in thermal-field flow fractionation, which are required for unambiguous results, are dealt with by a numerical and graphical peak shape analysis approach. Nonlinear effects, such as injected sample overloading as a function of sample concentration and field strength, can be detected by the Edgeworth-Cramér (EC) peak shape fitting method and the determination of relative statistical peak parameter determination. The physical implication of the nonlinearity effect is also discussed. Peak retention parameters by numerical integration are determined and the differences obtained by means of the above methods are compared.
Assessment of Linearity Conditions in Thermal Field-Flow Fractionation by Peak Shape Analysis
CONTADO, Catia;DONDI, Francesco
1997
Abstract
Linearity conditions in thermal-field flow fractionation, which are required for unambiguous results, are dealt with by a numerical and graphical peak shape analysis approach. Nonlinear effects, such as injected sample overloading as a function of sample concentration and field strength, can be detected by the Edgeworth-Cramér (EC) peak shape fitting method and the determination of relative statistical peak parameter determination. The physical implication of the nonlinearity effect is also discussed. Peak retention parameters by numerical integration are determined and the differences obtained by means of the above methods are compared.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
