The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues
SIMONI, Daniele;BARALDI, Pier Giovanni;LAMPRONTI, Ilaria;MANFREDINI, Stefano
1996
Abstract
The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.File in questo prodotto:
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