Variations of FV biological functions deriving from gene variations, and from their dynamic interactions with other genetic and environmental factors, will be studied to define associations and susceptibility to cardiovascular diseases. Spectra of loss-of-function and gain -of-function mutations will be investigated thus elucidating FV- related hemorrhagic and prothrombotic components. We will explore the hypothesis that multiple genetic variations that concomitantly alter the FV biological function may interact synergistically.
Progetto PRIN: MOLECULAR BASES OF ALTERED PROCOAGULANT AND ANTICOAGULANT FACTOR V FUNCTION IN VASCULAR DISEASES.
BERNARDI, Francesco
2001
Abstract
Variations of FV biological functions deriving from gene variations, and from their dynamic interactions with other genetic and environmental factors, will be studied to define associations and susceptibility to cardiovascular diseases. Spectra of loss-of-function and gain -of-function mutations will be investigated thus elucidating FV- related hemorrhagic and prothrombotic components. We will explore the hypothesis that multiple genetic variations that concomitantly alter the FV biological function may interact synergistically.File in questo prodotto:
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