The effects of several newly synthesized isoxazole analogues of retinoids on differentiation and proliferation of 'in vitro' cultured tumor cell lines are reported. Some of the tested compounds exhibit significative differentiating action, inducing adipogenic conversion of the Chinese hamster FH06T1-1 cell line in a range of 2-10 times the activity of retinoic acid and retinol.
New isoxazole derivatives of retinoids: Synthesis and activity on growth and differentiation of tumor cells
SIMONI, Daniele;MANFREDINI, Stefano;AGHAZADEH TABRIZI, Mojgan;BARALDI, Pier Giovanni;NASTRUZZI, Claudio;FERIOTTO, Giordana;GAMBARI, Roberto
1992
Abstract
The effects of several newly synthesized isoxazole analogues of retinoids on differentiation and proliferation of 'in vitro' cultured tumor cell lines are reported. Some of the tested compounds exhibit significative differentiating action, inducing adipogenic conversion of the Chinese hamster FH06T1-1 cell line in a range of 2-10 times the activity of retinoic acid and retinol.File in questo prodotto:
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