We report a new case of Ph positive chronic myeloid leukemia (CML) without the classical rearrangement in Mbcr. By Southern blot analysis the molecular breakpoint was mapped 3 to 8 kb upstream of Mbcr. This region has not been shown to be rearranged in any other described case of CML. We did not detect any specific abnormal BCR-ABL transcript even with the use of the very sensitive RNA-PCR technique.

A new chromosomal breakpoint in Ph positive, bcr negative chronic myelogenous leukemia. Report of a case

NEGRINI, Massimo
Primo
;
CUNEO, Antonio
Penultimo
;
CASTOLDI, Gianluigi
Ultimo
1992

Abstract

We report a new case of Ph positive chronic myeloid leukemia (CML) without the classical rearrangement in Mbcr. By Southern blot analysis the molecular breakpoint was mapped 3 to 8 kb upstream of Mbcr. This region has not been shown to be rearranged in any other described case of CML. We did not detect any specific abnormal BCR-ABL transcript even with the use of the very sensitive RNA-PCR technique.
1992
Negrini, Massimo; Tallarico, A; Pazzi, I; Castagnoli, A; Cuneo, Antonio; Castoldi, Gianluigi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1681287
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