Bisphosphonate-related osteonecrosis of the jaw is defined as an 'exposure of necrotic bone in maxillofacial region, which persists more than 8 weeks in patients treated or, in course of treatment with bisphosphonates, not been subjected to radiation therapy of the jaw. Bisphosphonates are compounds used to treat osteoporosis and malignant bone metastasis. Despite the benefits related to the use of these medications, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. This study was conducted to evaluate the correlation between the onset of ONJ and bisphosphonate treatment, through descriptive and statistical data analysis, extracted from our study population, and correlation with data offered by literature.
BISPHOSPHONATES-RELATED OSTEONECROSIS OF THE JAW: MULTICENTRE STUDY
CARINCI, Francesco;
2012
Abstract
Bisphosphonate-related osteonecrosis of the jaw is defined as an 'exposure of necrotic bone in maxillofacial region, which persists more than 8 weeks in patients treated or, in course of treatment with bisphosphonates, not been subjected to radiation therapy of the jaw. Bisphosphonates are compounds used to treat osteoporosis and malignant bone metastasis. Despite the benefits related to the use of these medications, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. This study was conducted to evaluate the correlation between the onset of ONJ and bisphosphonate treatment, through descriptive and statistical data analysis, extracted from our study population, and correlation with data offered by literature.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
