Some indole and pyrrolidone derivatives of two peptides, H-​Ile-​His-​Pro-​NH2 and N epsilon-​Boc-​Lys-​Ile-​His-​Pro-​NH2, were prepared and tested for antisecretory activity. A report is given of the synthetic scheme used for the two peptides which is a modified Jones procedure, the preparation of pyrrolidin-​5-​one-​N-​heptanoic acid and 1H-​indol-​3-​heptanoic acid, the introduction on the peptide chain of indole and pyrrolidone radicals and the results of the pharmacological investigation.

Synthesis of compounds of antisecretory activity.

BARALDI, Pier Giovanni;GUARNERI, Mario;VICENTINI, Chiara Beatrice;
1980

Abstract

Some indole and pyrrolidone derivatives of two peptides, H-​Ile-​His-​Pro-​NH2 and N epsilon-​Boc-​Lys-​Ile-​His-​Pro-​NH2, were prepared and tested for antisecretory activity. A report is given of the synthetic scheme used for the two peptides which is a modified Jones procedure, the preparation of pyrrolidin-​5-​one-​N-​heptanoic acid and 1H-​indol-​3-​heptanoic acid, the introduction on the peptide chain of indole and pyrrolidone radicals and the results of the pharmacological investigation.
1980
Baraldi, Pier Giovanni; DALLA VECCHIA, F.; Guarneri, Mario; Vicentini, Chiara Beatrice; Ceserani, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460388
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