In a clinical retrospectiue study, a follotu-up of lrypotlnlamo-amenonheic patients treated frstly with gonadotropin-releasing honnone (CnRH) pump stimulation and secondly with human menopausal gonadotropín ftMG) was performed. Thirty-two hypothalamo-amenorrheic patients, 24-38 years old, were subnútted to 1 03 CnRH stimulatiotr cycles . Seven, with polycystic ovaies (PCO) on ultrasound, were stirnulated with hMC after one or several unsuccessful pump cydes. Ouulatíon was confmted by a luteinizing hormone (LH) nrge or trigeretl by human choionicgonadotropin itr 80 out of 103 cycles (77.7%/cyde) Ieading to 62 timed sexual intercourses and 17 intrauterine inseminatíons (IUl. Twenty-one pregnancies (26.3%/cyde) terminated in eight abortions (38.1%/pregnancy) and 13 tleliveies (40.6%/patient). hMG stímulation, in the seuen PCO patients (six IVF, one IUI), Ied to four additional deliveríes ín three patíents. Fiue patients became pftgnant spontaneously after pump failure (n= 2) or wtsuccessfiú IVF (n= 3). Combining all cycles, 17 deliueries were obtaíned in 16 patíents. No case of ovarian hyperstimulation syndrome (OHSS) was obserued. GnRH is an eficient and sde treatment of hypothalamo-amenonheic-induced anovulation. Following CnRH or hMG ouarian sîimulation, spontaneous owúatiott and conception may be restored in certain hy p othalamo - amenorrheic p atients
Ovulation induction with pulsatile gonadotrophin-releasing hormone (GnRH) in women with hypotalamic amenorrhea.
MARCI, Roberto;
1996
Abstract
In a clinical retrospectiue study, a follotu-up of lrypotlnlamo-amenonheic patients treated frstly with gonadotropin-releasing honnone (CnRH) pump stimulation and secondly with human menopausal gonadotropín ftMG) was performed. Thirty-two hypothalamo-amenorrheic patients, 24-38 years old, were subnútted to 1 03 CnRH stimulatiotr cycles . Seven, with polycystic ovaies (PCO) on ultrasound, were stirnulated with hMC after one or several unsuccessful pump cydes. Ouulatíon was confmted by a luteinizing hormone (LH) nrge or trigeretl by human choionicgonadotropin itr 80 out of 103 cycles (77.7%/cyde) Ieading to 62 timed sexual intercourses and 17 intrauterine inseminatíons (IUl. Twenty-one pregnancies (26.3%/cyde) terminated in eight abortions (38.1%/pregnancy) and 13 tleliveies (40.6%/patient). hMG stímulation, in the seuen PCO patients (six IVF, one IUI), Ied to four additional deliveríes ín three patíents. Fiue patients became pftgnant spontaneously after pump failure (n= 2) or wtsuccessfiú IVF (n= 3). Combining all cycles, 17 deliueries were obtaíned in 16 patíents. No case of ovarian hyperstimulation syndrome (OHSS) was obserued. GnRH is an eficient and sde treatment of hypothalamo-amenonheic-induced anovulation. Following CnRH or hMG ouarian sîimulation, spontaneous owúatiott and conception may be restored in certain hy p othalamo - amenorrheic p atientsI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
