The reconstruction of bony defects is still a big concern for the oral surgeon. Autogenous bone is a good candidate for reconstruction, but it requires a second surgical procedure at a different site, involving additional time, extra cost, and potential for problems such as infection. At present, many bone-grafting products have been introduced. Allogro® (Ceramed, Lakewood, CO) is a demineralized freeze-dried bone allograft, useful as scaffold to fill bone defects and to restore bone loss in orthopedic and maxillofacial surgery. The present study showed that Allogro® leads to osteoblast phenotype expression and extracellular matrix deposition in ADSCs by the activation of osteoblast related genes SP7, COL1A1 and SPP1 and the under-expression of ENG.
AN IN VITRO STUDY ABOUT THE ALLOGRO® EFFECT ON ADIPOSE DERIVED STEM CELLS AND HUMAN OSTEOBLAST: A COMPARATIVE STUDY
CARINCI, Francesco;PALMIERI, Annalisa;SOLLAZZO, Vincenzo
2012
Abstract
The reconstruction of bony defects is still a big concern for the oral surgeon. Autogenous bone is a good candidate for reconstruction, but it requires a second surgical procedure at a different site, involving additional time, extra cost, and potential for problems such as infection. At present, many bone-grafting products have been introduced. Allogro® (Ceramed, Lakewood, CO) is a demineralized freeze-dried bone allograft, useful as scaffold to fill bone defects and to restore bone loss in orthopedic and maxillofacial surgery. The present study showed that Allogro® leads to osteoblast phenotype expression and extracellular matrix deposition in ADSCs by the activation of osteoblast related genes SP7, COL1A1 and SPP1 and the under-expression of ENG.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
