Advances in bone grafting are progressing with the evolution of biomaterials that permit the incorporation of osteoinductive and osteogenic proteins into osteoconductive composite scaffolds. Algipore®, a hydroxyapatite ceramic obtained from red alga, is largely employed as scaffolds in bone regeneration. For this reason, we studied if and how Algipore® can induce osteoblast differentiation in stem cells derived from adipose tissue, measuring the expression levels of bone related genes and mesenchymal stem cells marker by real time RT-PCR. The obtained results demonstrated that Algipore® enhances differentiation and deposition of matrix in stem cells by the activation of osteoblast and related genes FOSL1 , COL1A1, SPP1, SP7 and ALPL.

ALGIPORE® STIMULATES OSTEBLAST DIFFERENTIATION IN ADIPOSE DERIVED STEM CELLS

CARINCI, Francesco;PALMIERI, Annalisa;SOLLAZZO, Vincenzo
2012

Abstract

Advances in bone grafting are progressing with the evolution of biomaterials that permit the incorporation of osteoinductive and osteogenic proteins into osteoconductive composite scaffolds. Algipore®, a hydroxyapatite ceramic obtained from red alga, is largely employed as scaffolds in bone regeneration. For this reason, we studied if and how Algipore® can induce osteoblast differentiation in stem cells derived from adipose tissue, measuring the expression levels of bone related genes and mesenchymal stem cells marker by real time RT-PCR. The obtained results demonstrated that Algipore® enhances differentiation and deposition of matrix in stem cells by the activation of osteoblast and related genes FOSL1 , COL1A1, SPP1, SP7 and ALPL.
2012
G., Brunelli; Carinci, Francesco; A., Girardi; Palmieri, Annalisa; G. L., Caccianiga; A., Gigante; Sollazzo, Vincenzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1579465
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