The skin is indeed a very peculiar organ, displaying biochemical and immunological features specific for a compartment continuously exposed to external and endogenous stimuli. Skin lipids, with their unique biochemical composition, provide protection from environmental stressors although the formation of bioactive compounds such as 4-hydroxynonenal, oxysterols, and oxidized phospholipids can be a consequence of exposure to these stressors. These compounds derived mainly from the oxidation of the skin lipids are essential in the regulation of skin and mucosal tissue inflammation, since they are able to trigger, sustain, or terminate cutaneous inflammatory processes. Their function in the modulation of ROS, RNS, cytokine, and chemokine production and release, in DNA and protein oxidation, in gene expression, in the regulation of antioxidant and detoxifying enzymes, is under extensive investigation. Their control may therefore well represent a feasible tool for clinical interventions aiming at the correct modulation of skin physiological functions for possible disease prevention
Lipid mediators in skin inflammation: updates and current views
VALACCHI, Giuseppe;
2010
Abstract
The skin is indeed a very peculiar organ, displaying biochemical and immunological features specific for a compartment continuously exposed to external and endogenous stimuli. Skin lipids, with their unique biochemical composition, provide protection from environmental stressors although the formation of bioactive compounds such as 4-hydroxynonenal, oxysterols, and oxidized phospholipids can be a consequence of exposure to these stressors. These compounds derived mainly from the oxidation of the skin lipids are essential in the regulation of skin and mucosal tissue inflammation, since they are able to trigger, sustain, or terminate cutaneous inflammatory processes. Their function in the modulation of ROS, RNS, cytokine, and chemokine production and release, in DNA and protein oxidation, in gene expression, in the regulation of antioxidant and detoxifying enzymes, is under extensive investigation. Their control may therefore well represent a feasible tool for clinical interventions aiming at the correct modulation of skin physiological functions for possible disease preventionI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
