Adenosine interacts with four G-proteins coupled receptors named as A1, A2A, A2B and A3 adenosine receptors (ARs). A1 and A3ARs inhibit adenylate cyclase activity and decrease cAMP production whilst A2A and A2BARs exert an increase of cAMP accumulation. It has been accepted that A2A and/or A3 ARs are highly expressed in inflammatory and tumor cells showing a pivotal role in the inflammatory disorders.
Adenosine receptors in inflammatory disorders
VARANI, Katia
Primo
;BOREA, Pier AndreaUltimo
2012
Abstract
Adenosine interacts with four G-proteins coupled receptors named as A1, A2A, A2B and A3 adenosine receptors (ARs). A1 and A3ARs inhibit adenylate cyclase activity and decrease cAMP production whilst A2A and A2BARs exert an increase of cAMP accumulation. It has been accepted that A2A and/or A3 ARs are highly expressed in inflammatory and tumor cells showing a pivotal role in the inflammatory disorders.File in questo prodotto:
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