The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed. © 2010 Elsevier Ltd. All rights reserved.
Toward the optimization of continuous-flow aldol and alpha-amination reactions by means of proline-functionalized silicon packed-bed microreactors
MASSI, Alessandro;CAVAZZINI, Alberto;DEL ZOPPO, Luisa;PANDOLI, Omar;COSTA, Valentina;PASTI, Luisa;GIOVANNINI, Pier Paolo
2011
Abstract
The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed. © 2010 Elsevier Ltd. All rights reserved.File in questo prodotto:
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