Bio-Oss® an anorganic bovine bone largely employed in maxillary surgery for regeneration procedures is identical to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial alters osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that Bio-Oss® enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1 and the disappearance of the mesenchymal stem cells marker, ENG
BIO-OSS® STIMULATES OSTEOBLASTS DIFFERENTIATION IN DENTAL PULP DERIVED STEM CELLS
CARINCI, Francesco;PALMIERI, Annalisa;SOLLAZZO, Vincenzo
2011
Abstract
Bio-Oss® an anorganic bovine bone largely employed in maxillary surgery for regeneration procedures is identical to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial alters osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that Bio-Oss® enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1 and the disappearance of the mesenchymal stem cells marker, ENGI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
