Left ventricular hypertrophy (LVH) is both common and an important predictor of morbidity and mortality in end stage renal failure (ESRF). The aim of our study was to examine the prevalence of LVH in different stages of chronic renal failure (CRF) and which risk factors are involved in its development. We carefully selected 85 stable patients (37 M, 48 F), age 49 (plus or minus) 14 years, creatinine clearance (CrCl) 39 (plus or minus) 30 ml/min with no history of diabetes, ischaemic or valvular heart disease, cerebrovascular or peripheral vascular disease. They underwent 24 hr ambulatory blood pressure (BP) monitoring and echocardiography for left ventricular mass index (LVMI). Clinic BP, body mass index (BMI), serum creatinine (SCr), CrCl, haemoglobin (Hb), calcium (Ca), phosphate (P0(4)), parathyroid hormone (PTH) and 24 hr urinary protein exception were measured. Patients with CrCl < 30 ml/min (group 2) had higher proteinuria, P0(4), PTH, systolic BP (sBP) and LVMI, whilst HB was lower than in patients with CrCl > 30 ml/min (group 1), LVH was detected in 16% of patients in group 1 and 38% in group 2. By stepwise regression analysis, BMI, male gender, 24 hr sBP, and Hb were independent determinants of LVMI. We conclude that LVH is a common finding in pre- dialysis CRF. Decreasing sBP and correcting anaemia might reduce LVH, thus decreasing morbidity and mortality in ESRF.

Relation between left ventricular hypertrophy and blood pressure in chronic renal failure

FABBIAN, Fabio;
1998

Abstract

Left ventricular hypertrophy (LVH) is both common and an important predictor of morbidity and mortality in end stage renal failure (ESRF). The aim of our study was to examine the prevalence of LVH in different stages of chronic renal failure (CRF) and which risk factors are involved in its development. We carefully selected 85 stable patients (37 M, 48 F), age 49 (plus or minus) 14 years, creatinine clearance (CrCl) 39 (plus or minus) 30 ml/min with no history of diabetes, ischaemic or valvular heart disease, cerebrovascular or peripheral vascular disease. They underwent 24 hr ambulatory blood pressure (BP) monitoring and echocardiography for left ventricular mass index (LVMI). Clinic BP, body mass index (BMI), serum creatinine (SCr), CrCl, haemoglobin (Hb), calcium (Ca), phosphate (P0(4)), parathyroid hormone (PTH) and 24 hr urinary protein exception were measured. Patients with CrCl < 30 ml/min (group 2) had higher proteinuria, P0(4), PTH, systolic BP (sBP) and LVMI, whilst HB was lower than in patients with CrCl > 30 ml/min (group 1), LVH was detected in 16% of patients in group 1 and 38% in group 2. By stepwise regression analysis, BMI, male gender, 24 hr sBP, and Hb were independent determinants of LVMI. We conclude that LVH is a common finding in pre- dialysis CRF. Decreasing sBP and correcting anaemia might reduce LVH, thus decreasing morbidity and mortality in ESRF.
1998
Fabbian, Fabio; Tucker, B.; Squerzanti, R.; Lambertini, D.; Gilli, P.; Raine, A. E. G.; Baker, L. R. I.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1400460
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