Problem HLA-G antigen maintains a tolerogenic condition at the feto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings we analyzed if sHLA-G and IL-10 could be influenced by pregnancy and labour in allergic and non-allergic women. Method of Study sHLA-G isoforms and interleukin 10 (IL-10) levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. Results A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform. Conclusions The data propose an impressive boost in sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is the main responsible for the increased sHLA-G levels at delivery.
Allergic women have reduced sHLA-G plasma levels at delivery
RIZZO, Roberta;STIGNANI, Marina;BARICORDI, Olavio;
2009
Abstract
Problem HLA-G antigen maintains a tolerogenic condition at the feto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings we analyzed if sHLA-G and IL-10 could be influenced by pregnancy and labour in allergic and non-allergic women. Method of Study sHLA-G isoforms and interleukin 10 (IL-10) levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. Results A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform. Conclusions The data propose an impressive boost in sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is the main responsible for the increased sHLA-G levels at delivery.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
