Chemical manipulation of the nicotinic DMPP, endowed with modest activity on the central receptors, definitely improved its affinity and pharmacokinetic properties. Although their pharmacophore is somehow different from that of classical nicotinic ligands, some DMPP derivatives show low nanomolar affinity for the central nicotinic receptors.
Rigid analogs of DMPP as probes for the nicotinic receptors
VARANI, Katia
2005
Abstract
Chemical manipulation of the nicotinic DMPP, endowed with modest activity on the central receptors, definitely improved its affinity and pharmacokinetic properties. Although their pharmacophore is somehow different from that of classical nicotinic ligands, some DMPP derivatives show low nanomolar affinity for the central nicotinic receptors.File in questo prodotto:
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