Biological activity (mortality and genotoxicity) of four thiophene compounds [a-terthienyl (a-T); 5-(4-hydroxy-1-butinyl)-2,2'-bithienyl (BBTOH); 5-(3-buten-1-ynyl)-2,2'-bithienyl (BBT); 5-(4-acetoxy-1-butinyl)-2,2'-bithienyl (BBTOAc)] was evaluated on Saccharomyces cerevisiae D7 strain cells. An high percentage of mortality was found with BBTOAc at all concentrations tested. A significant effect was also detected with alpha-T but only at the highest concentration. BBTOH stimulated colonies growth only at the lowest concentration, while BBT showed no effects. None of the tested compounds presented genotoxic activity.
Biological activity of four thiophene compounds in resting Saccharomyces cerevisiae cells.
MUZZOLI, Mariavittoria;SACCHETTI, Gianni
2001
Abstract
Biological activity (mortality and genotoxicity) of four thiophene compounds [a-terthienyl (a-T); 5-(4-hydroxy-1-butinyl)-2,2'-bithienyl (BBTOH); 5-(3-buten-1-ynyl)-2,2'-bithienyl (BBT); 5-(4-acetoxy-1-butinyl)-2,2'-bithienyl (BBTOAc)] was evaluated on Saccharomyces cerevisiae D7 strain cells. An high percentage of mortality was found with BBTOAc at all concentrations tested. A significant effect was also detected with alpha-T but only at the highest concentration. BBTOH stimulated colonies growth only at the lowest concentration, while BBT showed no effects. None of the tested compounds presented genotoxic activity.File in questo prodotto:
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