Previous studies have reported cardiovascular and nociceptive responses after intrathecal injection of kinin B1 receptor (B1R) agonists in the model of streptozotocin (STZ)-diabetic rat (diabetic). The aim of this study was to measure the early up-regulation of B1R binding sites andmRNA in the thoracic spinal cord of diabetic and control rats. Data show signi¢cant increases of speci¢c B1R binding sites in the dorsal horn of diabetic rats 2 days (+315%), 7 days (+303%) and 21days (+181%) after STZ treatment. Levels of mRNAwere signi¢cantly increased (+68%) at 2 and 7 days but not at 21days.These data bring the ¢rstmolecular evidence for an early up-regulation of B1R in the spinal cord of diabetic rat. NeuroReport 15:2463^2466 c 2004 LippincottWilliams &Wilkins.
Expression of kinin B-1 receptors in the spinal cord of streptozotocin-diabetic rat
RODI, Donata;
2004
Abstract
Previous studies have reported cardiovascular and nociceptive responses after intrathecal injection of kinin B1 receptor (B1R) agonists in the model of streptozotocin (STZ)-diabetic rat (diabetic). The aim of this study was to measure the early up-regulation of B1R binding sites andmRNA in the thoracic spinal cord of diabetic and control rats. Data show signi¢cant increases of speci¢c B1R binding sites in the dorsal horn of diabetic rats 2 days (+315%), 7 days (+303%) and 21days (+181%) after STZ treatment. Levels of mRNAwere signi¢cantly increased (+68%) at 2 and 7 days but not at 21days.These data bring the ¢rstmolecular evidence for an early up-regulation of B1R in the spinal cord of diabetic rat. NeuroReport 15:2463^2466 c 2004 LippincottWilliams &Wilkins.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
