THe aims of our research were to investigate the TfR levels in patients with heart valve prosthesis (mechanical or biological); in order a) to compare TfR values with the other well-known indexes of haemolysis -hemoglobn concentration (Hb), reticulocyte count (retics), serum bilirubin, serum lactate dehydrogenanse activity (sLDH), haptoglobin-, and b) to evaluate in such patients the utility of TfR determination as a good index of the erythropoietic response to traumatic haemolysis. On the basis of our preliminary results, we suggest that in patients with heart valve prosthesis, the study of TfR, in association with previously reported indexes, would be useful to estimate if traumatic red cell destruction is completely compensated, as well as to identify underlying desorders of erythropoiesis mostly related to hypoproliferative bone-marrow condition.
The determination of plasma transferrin receptor (TfR) in patients with heart valve prosthesis: a useful evaluation of bone‐marrow response to traumatic haemolysis
RICCI, Giorgio;
1995
Abstract
THe aims of our research were to investigate the TfR levels in patients with heart valve prosthesis (mechanical or biological); in order a) to compare TfR values with the other well-known indexes of haemolysis -hemoglobn concentration (Hb), reticulocyte count (retics), serum bilirubin, serum lactate dehydrogenanse activity (sLDH), haptoglobin-, and b) to evaluate in such patients the utility of TfR determination as a good index of the erythropoietic response to traumatic haemolysis. On the basis of our preliminary results, we suggest that in patients with heart valve prosthesis, the study of TfR, in association with previously reported indexes, would be useful to estimate if traumatic red cell destruction is completely compensated, as well as to identify underlying desorders of erythropoiesis mostly related to hypoproliferative bone-marrow condition.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.