Our study provide information on FVII residue important for interaction with substrates and cofactors. Moreover, the comparison of the in vitro and in vivo mutations, potentially affecting the identical residues encoded by putative hot spot mutational sites, help to interpretate unexpected differences in the incidence of FVII variants within the population.
Comparison among natural (Arg304Gln, Arg304Trp) and artificial (Arg290His, Arg290Lys) mutations in coagulation factor VII loops.
FURLAN FREGUIA C;GEMMATI, Donato;BERNARDI, Francesco
2003
Abstract
Our study provide information on FVII residue important for interaction with substrates and cofactors. Moreover, the comparison of the in vitro and in vivo mutations, potentially affecting the identical residues encoded by putative hot spot mutational sites, help to interpretate unexpected differences in the incidence of FVII variants within the population.File in questo prodotto:
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