A new water-soluble multi-charged monoadduct fullero[60]pyrrolidine derivative with three ethylene glycol chains and three ammonium groups has been synthesized by means of two alternative synthetic pathways. Increasing the concentration of this C60 derivative did not show a significant modification of concentration of superoxide anion radical O2·−, generated by the xanthine/xanthine oxidase system. Moreover, this C60 derivative was ineffective for neuroprotection in quantitative assessment of a neuronal injury considered to occur via radicals.
A new multi-charged C60 derivative: synthesis and biological properties
TOMASINI, Maria Cristina;ANTONELLI, Tiziana;FERRARO, Luca Nicola;
2002
Abstract
A new water-soluble multi-charged monoadduct fullero[60]pyrrolidine derivative with three ethylene glycol chains and three ammonium groups has been synthesized by means of two alternative synthetic pathways. Increasing the concentration of this C60 derivative did not show a significant modification of concentration of superoxide anion radical O2·−, generated by the xanthine/xanthine oxidase system. Moreover, this C60 derivative was ineffective for neuroprotection in quantitative assessment of a neuronal injury considered to occur via radicals.File in questo prodotto:
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