Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc≡N multiple bond, under conditions suitable for nuclear medicine applications, new radio-pharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride Tcv complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting inter-esting biological properties. The peculiar chemical characteristics of the Tc=N core can also be conveniently utilized for the design of radiopharmaceuticals incorporating bioactive peptides and having definite structural features. © 1997 Chapman & Hall.

Technetium-99m nitride radiopharmaceuticals

UCCELLI, Licia;DUATTI, Adriano;
1997

Abstract

Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc≡N multiple bond, under conditions suitable for nuclear medicine applications, new radio-pharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride Tcv complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting inter-esting biological properties. The peculiar chemical characteristics of the Tc=N core can also be conveniently utilized for the design of radiopharmaceuticals incorporating bioactive peptides and having definite structural features. © 1997 Chapman & Hall.
1997
C., Bolzati; Uccelli, Licia; Duatti, Adriano; Zucchini, G. L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1201658
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