Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc≡N multiple bond, under conditions suitable for nuclear medicine applications, new radio-pharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride Tcv complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting inter-esting biological properties. The peculiar chemical characteristics of the Tc=N core can also be conveniently utilized for the design of radiopharmaceuticals incorporating bioactive peptides and having definite structural features. © 1997 Chapman & Hall.
Technetium-99m nitride radiopharmaceuticals
UCCELLI, Licia;DUATTI, Adriano;
1997
Abstract
Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc≡N multiple bond, under conditions suitable for nuclear medicine applications, new radio-pharmaceuticals for heart and brain imaging have been discovered. These compounds belong to the class of bi-substituted, square-pyramidal nitride Tcv complexes with dithiocarbamate ligands, and are the first examples of radiopharmaceuticals of this type exhibiting inter-esting biological properties. The peculiar chemical characteristics of the Tc=N core can also be conveniently utilized for the design of radiopharmaceuticals incorporating bioactive peptides and having definite structural features. © 1997 Chapman & Hall.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.