The addition of organomagnesium compounds to the N-benzyl 2-thiazolyl nitrone 1 in the presence of various chiral additives and Lewis acids leads to hydroxylamines 2 in moderate to good enantiomeric excess (up to 74%); the reductive dehydroxylation of these compounds affords enantioenriched α-amino 2-alkylthiazoles 3 in good yields (76-66%).
Enantioselective addition of Grignard reagents to a 2-thiazolyl nitrone
DONDONI, Alessandro
1996
Abstract
The addition of organomagnesium compounds to the N-benzyl 2-thiazolyl nitrone 1 in the presence of various chiral additives and Lewis acids leads to hydroxylamines 2 in moderate to good enantiomeric excess (up to 74%); the reductive dehydroxylation of these compounds affords enantioenriched α-amino 2-alkylthiazoles 3 in good yields (76-66%).File in questo prodotto:
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