The addition of organomagnesium compounds to the N-benzyl 2-thiazolyl nitrone 1 in the presence of various chiral additives and Lewis acids leads to hydroxylamines 2 in moderate to good enantiomeric excess (up to 74%); the reductive dehydroxylation of these compounds affords enantioenriched α-amino 2-alkylthiazoles 3 in good yields (76-66%).

Enantioselective addition of Grignard reagents to a 2-thiazolyl nitrone

DONDONI, Alessandro
1996

Abstract

The addition of organomagnesium compounds to the N-benzyl 2-thiazolyl nitrone 1 in the presence of various chiral additives and Lewis acids leads to hydroxylamines 2 in moderate to good enantiomeric excess (up to 74%); the reductive dehydroxylation of these compounds affords enantioenriched α-amino 2-alkylthiazoles 3 in good yields (76-66%).
1996
Merchan, Fl; Merino, P; Rojo, I; Tejero, T; Dondoni, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1201465
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