The addition reaction of diethyl phosphite to O-silylated N-benzyl nitrones derived from chiral alpha-alkoxy and N-Boc alpha-amino aldehydes has been studied as a stereoselective carbon-phosphorus bond forming process for the synthesis of polyhydroxylated alpha-amino and alpha,beta-diamino phosphonates. Key intermediates are the corresponding N-hydroxy alpha-amino phosphonates.
O-Silyl triflate-promoted addition of diethyl phosphite to chiral aldonitrones. A rapid access to complex alpha-amino phosphonates and their N-hydroxy derivatives
DE RISI, Carmela;DONDONI, Alessandro;PERRONE, Daniela;POLLINI, Gian Piero
2001
Abstract
The addition reaction of diethyl phosphite to O-silylated N-benzyl nitrones derived from chiral alpha-alkoxy and N-Boc alpha-amino aldehydes has been studied as a stereoselective carbon-phosphorus bond forming process for the synthesis of polyhydroxylated alpha-amino and alpha,beta-diamino phosphonates. Key intermediates are the corresponding N-hydroxy alpha-amino phosphonates.File in questo prodotto:
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