A new approach to a solution-phase oligosaccharide synthesis using an excess of glycosyl acceptor and removal of the unreacted residue by an orchestrated sequence of very efficient steps employing trichloroacetyl isocyanate as sequestering enabling reagent (SER) is described. It is also illustrated the hybrid solution/solid-phase synthesis of oligosaccharide products based on the use of the levulinoyl ester group as masked tag in a ”resin-capture-release” purification strategy.

Hybrid solution/solid-phase synthesis of oligosaccharides by using trichloroacetyl isocyanate as sequestration-enabling reagent of sugar alcohols

DONDONI, Alessandro;MARRA, Alberto;MASSI, Alessandro
2005

Abstract

A new approach to a solution-phase oligosaccharide synthesis using an excess of glycosyl acceptor and removal of the unreacted residue by an orchestrated sequence of very efficient steps employing trichloroacetyl isocyanate as sequestering enabling reagent (SER) is described. It is also illustrated the hybrid solution/solid-phase synthesis of oligosaccharide products based on the use of the levulinoyl ester group as masked tag in a ”resin-capture-release” purification strategy.
2005
Dondoni, Alessandro; Marra, Alberto; Massi, Alessandro
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1201388
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 20
social impact