The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.

Stochastic Theory of Multiple-Site Linear Adsorption Chromatography

CAVAZZINI, Alberto;REMELLI, Maurizio;DONDI, Francesco;
1999

Abstract

The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.
1999
Cavazzini, Alberto; Remelli, Maurizio; Dondi, Francesco; A., Felinger
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1200703
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 70
social impact