The general rate model of chromatography can be coupled with the generalized Maxwell-Stefan equation that describes the surface diffusion flux. The resulting model is useful to describe the behavior of two enantiomers during their separation on chiral phases, cases in which the mass transfer kinetics is known to be sluggish. A case in point is the modeling of the elution profiles of the racemic mixture of the two enantiomers of 1-phenyl-1-propanol on cellulose tribenzoate coated on silica, a popular chiral stationary phase. The competitive equilibrium isotherm behavior of the two enantiomers on the chiral stationary phase was described using the competitive Tóth isotherm model. An excellent agreement between the experimental and the calculated profiles was observed in the whole range of experimental conditions investigated, at low and high column loadings.

Application of the general rate model and the generalised Maxwell-Stefan equation to the study of the mass transfer kinetics of a pair of enantiomers

CAVAZZINI, Alberto;
2002

Abstract

The general rate model of chromatography can be coupled with the generalized Maxwell-Stefan equation that describes the surface diffusion flux. The resulting model is useful to describe the behavior of two enantiomers during their separation on chiral phases, cases in which the mass transfer kinetics is known to be sluggish. A case in point is the modeling of the elution profiles of the racemic mixture of the two enantiomers of 1-phenyl-1-propanol on cellulose tribenzoate coated on silica, a popular chiral stationary phase. The competitive equilibrium isotherm behavior of the two enantiomers on the chiral stationary phase was described using the competitive Tóth isotherm model. An excellent agreement between the experimental and the calculated profiles was observed in the whole range of experimental conditions investigated, at low and high column loadings.
2002
K., Kaczmarski; Cavazzini, Alberto; P., Szabelski; D., Zhou; X., Liu; G., Guiochon
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1200693
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 36
social impact