Aim of the present paper was to investigate the influence of preparation parameters on gelatin microspheres production, chemico-physical characteristics and drug encapsulation. In particular, we focused our attention on the manufacturing parameters such as amount of polymer, stirring speed, presence and concentration of surfactants. As model drugs, TAPP-Br, clonidine hydrochloride and bromocriptine mesylate were chosen, in order to compare their encapsulation and release characteristics from microspheres. In the second part of the work is reported a study of the influence of thermal treatment on the microspheres, performed with the aim to possibly modify gelatin dissolution and drug release. In particular the effect of this treatment was evaluated on microspheres characteristics of the microspheres such as swelling, porosity and dissolution, and finally on the release profiles of the encapsulated drugs.
Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties
ESPOSITO, Elisabetta;CORTESI, Rita;NASTRUZZI, Claudio
1996
Abstract
Aim of the present paper was to investigate the influence of preparation parameters on gelatin microspheres production, chemico-physical characteristics and drug encapsulation. In particular, we focused our attention on the manufacturing parameters such as amount of polymer, stirring speed, presence and concentration of surfactants. As model drugs, TAPP-Br, clonidine hydrochloride and bromocriptine mesylate were chosen, in order to compare their encapsulation and release characteristics from microspheres. In the second part of the work is reported a study of the influence of thermal treatment on the microspheres, performed with the aim to possibly modify gelatin dissolution and drug release. In particular the effect of this treatment was evaluated on microspheres characteristics of the microspheres such as swelling, porosity and dissolution, and finally on the release profiles of the encapsulated drugs.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
